What the Research Says About Stem Cells and Spine Pain
Most clinical trials of stem cells for disc-related pain have focused on the lumbar spine (lower back), so their results cannot be assumed to apply to the neck. The lower-back evidence itself is mixed:
- A randomized trial of 24 patients with lumbar disc degeneration found that those who received donor bone marrow MSCs improved faster and more than a sham group over one year, and their disc degeneration scores improved while the control group's worsened (Noriega et al., Transplantation, 2017).
- The largest placebo-controlled trial to date, RESPINE, randomized 114 patients with chronic low back pain. At 12 months, 74% of MSC patients and 69% of sham patients met the response threshold—not a significant difference—and no serious adverse events related to the procedure occurred (Pers et al., Annals of the Rheumatic Diseases, 2024).

On safety, a review of 55 randomized trials of MSCs delivered into the bloodstream found an increased rate of temporary fever but no increase in infection, blood clots, death, or cancer (Thompson et al., EClinicalMedicine, 2020). Renovo shares this full picture before recommending any treatment.



